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desvenlafaxine will improve the amount or result of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Warning/Keep track of. Desvenlafaxine inhibits CYP2D6; with larger desvenlafaxine doses (ie, 400 mg) decrease the CYP2D6 substrate dose by up to 50%; no dosage adjustment needed with desvenlafaxine doses seven consecutive times promptly